How To Calculate Creatinine Clearance


It is a breakdown result of creatine phosphate in muscle. Typically created at a genuinely steady rate by the body contingent upon bulk. Creatinine is filtered but not reabsorbed in the kidney.

Creatinine Clearance

Creatinine freedom might be characterized as the volume (ml) of plasma that would be totally freed from creatinine every moment.

Creatinine Clearance Normal Range

The normal range of creatinine clearance is around 90-120 ml/min.

Serum creatinine normal range:-

  • Adult male: 0.7-1.4 mg/dl
  • Adult female: 0.6-1.3 mg/dl
  • Children: 0.5-1.2 mg/dl

Creatinine Clearance How To Calculate

Creatinine clearance (C) can be calculated as follows:


  • U=Concentration of creatinine in urine (mg/dl).
  • V=Volume of urine (ml/min).
  • P Concentration of the creatinine in plasma.

How Is The Sample Collected For Creatinine Clearance Testing

The test requires a 24-hour urine collection and a blood sample drawn either at the beginning or end of the urine collection.

Blood Serum creatinine levels are used to measure glomerular filtration rate levels in your urine.

A 24-hour urine sample is used to measure creatinine levels in your urine.


Certain factors or conditions may interfere with the accuracy of a 24-hour urine collection, including the following:-

  • Forgetting to collect some of the urine.
  • Going beyond the 24 hour collection period and collecting excess urine.
  • Losing urine from specimen container through spilling.

Patient Instruction For Creatinine Clearance Test

  • The accuracy of the test results depends on the accuracy of the specimen collection
  • It is significant that dust from garments not add to the example content.
  • Try not to gather pee in metal glass compartments.
  • Females: Do not collect urine while menstruating.
  • Do not remove preservatives from the bottle.
  • Keep the bottle upright so it does not spill.
  • Keep out of reach of children.
  • Record the time and date on the collection container label as the start time and date.


  • It is a normal endogenous substance.
  • It does not require I.V. administration.
  • The estimation of creatinine is simple.


  • A decrease in creatinine clearance value (<75%-normal) serves as a sensitive indicator of a decreased GFR, due to renal damage.
  • It is useful for early detection of impairment in kidney function.


Clearance studies are widely used to assess glomerular filtration rate and renal blood flow and to study the excretion of various substances by the kidney. Clearance is defined as the volume of blood or plasma which contains the amount of the substance that is excreted in the urine in one minute.

Renal Clearance How To Calculate

Renal clearance (C) can be calculated as follows Clearance (ml/min) UxV/P

  • U= Concentration of the substance in urine.
  • V= Volume of urine in ml excreted per minute.
  • P= Concentration of the substance in plasma.

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